Human cationic trypsinogen ( PRSS 1 ) variants and chronic pancreatitis 2 3 Balázs
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چکیده
1 Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis 2 3 Balázs Csaba Németh and Miklós Sahin-Tóth* 4 5 Department of Molecular and Cell Biology, Henry M. Goldman School of Dental Medicine, 6 Boston University, Boston, MA 02118 7 8 9 10 11 *Correspondence to Miklós Sahin-Tóth, 72 East Concord Street, Evans-433; Boston, MA 02118; 12 Tel: (617) 414-1070; Fax: (617) 414-1041; E-mail: [email protected] 13 14 Articles in PresS. Am J Physiol Gastrointest Liver Physiol (January 23, 2014). doi:10.1152/ajpgi.00419.2013
منابع مشابه
Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis.
Variations in the serine protease 1 (PRSS1) gene encoding human cationic trypsinogen have been conclusively associated with autosomal dominant hereditary pancreatitis and sporadic nonalcoholic chronic pancreatitis. Most high-penetrance PRSS1 variants increase intrapancreatic trypsin activity by stimulating trypsinogen autoactivation and/or by inhibiting chymotrypsin C-dependent trypsinogen degr...
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